The Brain-Gut-Skin Connection: Prebiotics Food

A prebiotic is defined as a selectively fermented ingredient that allows specific changes, both in the composition and/or activity in the gastrointestinal microflora that confers benefits upon host well-being and health.1   Based on the Brain-Gut-Skin connection, selectively promoting beneficial bacteria in your gut microbiome using prebiotics food could lead to a healthier mentality and a clearer skin.

Not all dietary carbohydrates are prebiotics.  There are three criteria are for a food substance to be qualified as prebiotics: 1) resistance to gastric acidity, to hydrolysis by mammalian enzymes, and to gastrointestinal absorption; 2) fermentation by intestinal microflora; and 3) selective stimulation of the growth and/or activity of those intestinal bacteria that contribute to health and well-being.  Based on these criteria, there are some food substances with prebiotics activities:

Inulin
Inulin is a nondigestible oligosaccharide that, for nutritional labeling, classifies as dietary fiber.  Inulin is a generic term that covers all β (1←2) linear molecules. The selective stimulation of bacterial growth by inulin has been confirmed by numerous In vitro studies.  In addition, in vivo studies using animal models have also confirmed the bifidogenic effect of inulin-type fructans.  Human trials with oligofructose and inulin with both adults and formula-fed infants have further confirmed the prebiotic effect of inulin-type fructans. 

Food rich with inulin include chicory, artichokes, burdock roots (a popular Japanese food), dandelion roots (which interestingly is used as a herb in the Chinese Medicine), Yacon (another common Adian food), leeks, onions, garlics, banana, rye and barley.

Trans-Galactooligosaccharides (TOS or GOS)
The TOS are a mixture of oligosaccharides derived from lactose by enzymatic transglycosylation. They generally consist of oligosaccharides from tri- to pentasaccharide with β (1→6), β (1→3), and β (1→4) linkages.  Several studies using animal models and human subjects have shown that a TOS-containing diet selectively increases bifidobacteria and lactobacilli (i.e., beneficial bacteria) and decrease in enterobacteria (i.e., bad bacteria). Infant formula milk supplemented with a mixture of oligosaccharides (90% galactooligosaccharides and 10% inulin) has been shown to increase bifidobacteria in both preterm and term infants.

TOS have been used as food ingredients in Japan and Europe for at least 30 years. It all started in Japan, where Japanese companies like Yakult Honsha (Tokyo, Japan) and Nissin Sugar Manufacturing Company (Tokyo, Japan) produced GOS for food applications. Later on Snow Brand Milk Products (Tokyo, Japan), FrieslandCampina Domo (ex Borucolo ingredients and Friesland Foods Domo) in the Netherlands and Clasado Ltd in the United Kingdom also started to produce GOS. Nowadays, GOS is mostly used for application in infant nutrition.

Additional prebiotics
Glucooligosaccharides, isomaltooligosaccharides, lactosucrose, polydextrose, soybean oligosaccharides, and xylooligosaccharides are oligosaccharides for which preliminary data already exist seem to support their prebiotic activity.  Other suggested prebiotic food substance include germinated barley foodstuffs, oligodextrans, gluconic acid, gentiooligosaccharides, pectic oligosaccharides, mannan oligosaccharides, lactose, glutamine, and hemicellulose-rich substrate, resistant starch and its derivatives, oligosaccharides from melibiose, lactoferrin-derived peptide, and N-acetylchitooligosaccharides.

Yeah, I know—that’s a lot of chemical names in the above paragraph!  The gist is that many of these compounds are good fibers usually rich in beans, bean sprouts, nuts, vegetables from onion family (such as leek), legumes, asparagus and other plant foods.  So, your mom is right—eat your vegetables, science says that they are truly good for you.

1. Roberfroid MB (March 2007). "Prebiotics: The Concept Revisited". J Nutr. 137 (3 Suppl 2): 830S–7S.

Thanks for reading!
Connie




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